Hyperhomocysteinemia and its relations to conventional risk factors for cardiovascular diseases in adult Nigerians: the REMAH study

Abstract Background Evidence linking homocysteine (Hcy) with cardiovascular diseases (CVD) or its risk factors are limited in a sub-Saharan black population. Objective We set out to evaluate the association between Hcy and hypertension other CVD population of adult Nigerians. Methods Data 156 adults aged 18–70 years was accessed from North Central study site REmoving MAsk on Hypertension (REMAH) study. Homocysteine, blood glucose lipid profile whole blood/serum were measured using standard laboratory methods. diagnosed if average 5 consecutive pressure (BP) measurements obtained mercury sphygmomanometer equal higher than 140 systolic and/or 90 mmHg diastolic individual is antihypertensive medication. Hyperhomocysteinemia (HHcy) defined as > 10 µmol/L. Results Of participants, 72 (43.5%) hypertensive, whom 18 had HHcy. Subjects HHcy significantly (p < 0.05) older (41.5 vs. 40.6yrs), lower HDL-cholesterol (0.6 0.8 mmol/L) (145.5 126.0 mmHg) BP (92.9 79.6 mmHg), compared those without Intake alcohol 1 yr increase age respectively associated 1.54 0.10 µmol/L Hcy. In multivariable model adjusted for age, sex body mass index, Hcy, 1.69 1.34 0.0001) respectively; 0.01 mmol/L decrease 0.05). Conclusion occurs among hypertensive Nigerians it independently HDL-cholesterol, BP.